METHYLATION PROFILE OF CANCER TESTIS ANTIGENS IN COLORECTAL CANCER

Methylation Profile of Cancer Testis Antigens in Colorectal Cancer

Background: Cancer testis antigens (CTAs) are a class of immune-stimulating antigens CREAM often overexpressed in many types of cancers.The usage of the CTAs as immunotherapy targets have been widely investigated in different cancers including melanoma, hematological malignancies, and colorectal cancer.Studies have indicated that the epigenetic reg

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Regulatory Dynamics of Tet1 and Oct4 Resolve Stages of Global DNA Demethylation and Transcriptomic Changes in Reprogramming

Summary: Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) involves the reactivation of endogenous pluripotency genes and global DNA demethylation, but temporal resolution of these events using existing markers is limited.Here, we generate murine transgenic Body Armor / Protection lines harboring reporters for the 5-methylcyto

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